Structure-system correlation identifies a gene regulatory Mediator submodule
نویسندگان
چکیده
منابع مشابه
Structure-system correlation identifies a gene regulatory Mediator submodule.
A combination of crystallography, biochemistry, and gene expression analysis identifies the coactivator subcomplex Med8C/18/20 as a functionally distinct submodule of the Mediator head module. Med8C forms a conserved alpha-helix that tethers Med18/20 to the Mediator. Deletion of Med8C in vivo results in dissociation of Med18/20 from Mediator and in loss of transcription activity of extracts. De...
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Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-r...
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Inferring the network structure of gene regulatory networks is one of the most important problems in contemporary bioinformatics. We analyze different methodologies for inferring small to very large sized gene networks. We use the datasets of DREAM 3 in-silico network challenge that is provided online [1]. The challenge involves inferring primarily the network structure from steady state gene e...
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Temporally-regulated expression of endogenous genes is a desirable goal in stable cell line and transgenic animal systems, as well as in clinical gene therapy. Protocols for introducing genes into stable cell lines and experimental animals are often unsatisfactory due to the constitutive expression of such transgenes. To circumvent this problem we have demonstrated specific and temporally regul...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2008
ISSN: 0890-9369
DOI: 10.1101/gad.465108